- Wat Phu Dan Tae (Wat Phuttho Thammatharo)
- The Second Thai-Lao Friendship Bridge(Mukdahan-Savannakhet)
- Namtok Kham Cha-I
- Ho Kaeo Mukdahan
- Wat Phra Si Maha Pho
Mukdahan, the pearl on the bank of the Mekong, has been a Historical gateway to Indochinese countries, and the population of the province reflects this: 8 different ethnic minorities live in Mukdahan; namely, Thai Isan, Phu Thai, Thai Kha, Kraso, Thai Kaloeng, Thai Yo, Thai Saek, and Thai Kula. Mukdahan has abundant natural beauty and is also famed for its high-quality Mudmee silk.
When visiting Mukdahan, visitors should not miss Skyscraping Ho Kaeo Tower, Phu Pha Thoep and Kaeng Kabao, Eight Ethnic Minorities, Famous Sweet Tamarind, Large Ancient Kettledrum, Origin of Lam Phaya, Stunning view of the Mekong River, Gateway to Indochina.
The local people of Mukdahan have had a long relationship with the people in Savannakhet province of neighbouring Laos, with whom they share a 70 km long Mekong River border.